Product Name : Di Calcium Phosphate
CAS : 7757-93-9
Molecular Formula : CaHPO4
Molecular Weight : 136.06 g/mol
Therapeutic Category : Oral
Global Calcium is one of the leading manufacturers and exporters of Di Calcium Phosphate CAS no. 7757-93-9, Mineral Actives . We support the customers with exhaustive documentation. As a USDMF & EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979.
As manufacturer of Di Calcium Phosphate we hereby state the following facts about the drug:
Dicalcium phosphate (DCP) is an insoluble inorganic diluent. The anhydrous (triclinic crystal) and dihydrate (monoclinic structure) forms of DCP are used in pharmaceutical development. The dihydrate form of DCP presents good flow properties and low hygroscopicity. Based on the temperature and humidity, the dihydrate form tends to lose water of hydration, which can cause the chemical instability of APIs in dosage forms. Because of the absence of water in its crystal structure, the anhydrous form of DCP exhibits higher porosity, leading to better compressibility and faster disintegration. The dihydrate form transforms (partially or wholly) to the anhydrous form because of the high temperature in the wet granulation process. Comparison between the two forms of DCP showed that the anhydrous form has better intraparticular porosity and better compressibility than the dihydrate form. In addition, because of the higher intraparticular porosity, the disintegration of anhydrous DCP is better than the dihydrate form. Both forms of DCP, however, needed a swelling-type disintegrant in the formulation when used. Different grades of DCP are available, with coarse grade used for direct compression and milled grade for wet granulation or roller compaction. The milled grade has an alkaline pH and cannot be used with API incompatible with basic pH.
Therapeutic uses and effectiveness:
2 CaHPO4 → Ca2P2O7 + H2O
Global Calcium is a leading manufacturer of this drug. We manufacture this pharmaceutical drug and make it available to domestic and overseas market